The inactive catalytic domain of HD-PTP could therefore act as a phospho-tyrosine binding module, also called STYX domain, which may control cell signaling pathways by preventing the dephosphorylation of its binding partners or by regulating their cellular localization [27], [33].
Examination of the model structure revealed that the aminoacidic substitutions were introduced not only in the catalytic module but also in the CMB as well as the linker region binding them.
Preservation can be seen as the similarity of co-expression between genes in a module, but also connectivity patterns of individual modules for the two data sets.
Preservation is the similarity of interconnections between genes in a module, but also connectivity patterns of individual modules for the two data sets, i.e. high preservation is evidence for densely connected, distinct, and reproducible modules.
It contains two BRCT domains at the C-terminus, i.e., phospho-peptide binding modules also carried by several proteins involved in the DNA damage response.
More recently, several non-catalytic carbohydrate binding modules (CBMs) have also been reported to show great potential as specific and versatile markers of carbohydrates in plant materials [ 15- 19].
The DNA/PIP-binding domain [ 12], which constitutes the NLS motif [ 7] and comprises the polybasic region adjacent to the zinc-binding module, is also well conserved, as are the NoLS motif, SID domain and the acidic central region that contributes to histone and nucleosome binding [ 7, 8, 12].
For HiGH61D, HiGH61H, and HiGH61I, the extra domain was identified as a family 1 carbohydrate-binding module (CBM1; also known as fungal cellulose-binding domain) (Gilkes et al. 1991), whereas HiGH61J has a C-terminal extension of ∼35 residues of unknown function.
Of course, a complete view of modularity should not only examine the effects of integration within modules on module disparity, but also how the parcellation of a system into modules influences the morphological evolution of the entire system.
FOS therefore not only links the modules, but also links the important pathways of these modules.
