Your English writing platform
Discover LudwigSuggestions(1)
Exact(2)
Comparison of the three-dimensional structures in complex with MHC suggests major differences in hydrogen bonding patterns with H2Kb, despite sharing similar binding modes, which may account for the differences in affinity and immunogenicity.
This lack of consensus may reflect the existence of several lncRNA-PRC2 binding modes, which may each correspond to distinct functions of the PRC2 complex.
Similar(58)
The third and final group collects all other modes, which may or may not be present in the final design.
Molecular modelling study revealed different binding modes which might underlie the observed opposing biological activities.
Interestingly, the indirubin E804 complex exhibits two binding modes which can be explained by the near-symmetrical core scaffold.
The latter points to distinctly different stable binding modes, which terminate at different locations in the G31−L100 segment.
Additionally, the agarose gel electrophoresis revealed that the Pt II) part could also offer DNA binding activity, suggesting the complexes possess a combined action mode which may help to overcome the resistance of cisplatin.
Figure 6 schematically illustrates how the SL1 binding mode, which anchors the N-terminus of αS in the lipoprotein complex while the more hydrophobic NAC region remains disordered, is prone to intermolecular interactions which may progress toward disease-associated oligomers and fibrils.
A subsequently determined structure of Sorafenib with c-Raf revealed an overall similar binding mode, which was termed a 'type II' binding mode.
AC-D employs an entirely novel binding mode, which differs from the amphipathic helix method used by many transcriptional activators.
Genotypic variations at SNP positions bring new possible binding sites, which may introduce novel modes of gene regulation, altering gene expression and thereby impacting disease progression.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com