Sentence examples for binding modes that may from inspiring English sources
Further, they show new binding modes that may also apply to natural protein substrates of PKAc, which have not been revealed by previous crystallographic studies.
This homotetrameric protein wraps ssDNA in multiple distinct binding modes that may be used selectively in different DNA processes, and whose detailed wrapping topologies remain speculative.
To rationalize the affinity and selectivity profiles, we analyzed poses from previous docking studies to a DYRK1a-derived homology model of DYRK2, which showed that compound 6i may adopt a binding mode that is significantly different from the experimentally established indirubin-kinase binding mode.
To understand the binding mode of these inhibitors on SRA, we conducted systematic molecular modeling studies in order to identify putative binding domain(s) that may be responsible for their recognition to the receptor as well as their inhibitory activity.
In summary, existing biochemical SAR is consistent with an essential role for all four polar atoms of the benzimidazole carboxamide scaffold in its binding to CHK2 and we postulated that alternative binding modes may better explain this SAR.
Otherwise, the readers may feel that the two binding modes may be of peculiar novelty that may be of no physiological consequences.
The fact that both proteins appear to bind syntaxin-1 via different binding modes may account for this non-redundancy (Parsaud et al., 2013).
Glorund binds to other RNAs in a different manner and probably regulates their splicing, suggesting that the use of different binding modes may increase the functional versatility of RNA-binding proteins.
The findings in this work suggest that the ability of the DBD to access different binding modes may be a possible point of regulation.
Comparison of the different binding modes suggests that avoiding the deep insertion of inhibitors into the transmembrane helix bundle may be able to preserve chemokine-CCR5 interactions.
