Sentence examples for binding modes that have from inspiring English sources

This is the case of the binding modes that have a Gln or Asp at pos. −1 that show different solvation patterns in the finger I crystals and in the validation dataset for finger II models.

The two closely related binding modes that have been proposed for the published class of benzimidazole CHK2 inhibitors both postulate that a pendant carboxamido substituent on the benzimidazole scaffold interacts directly with the hinge (Fig. 1).

It is assumed that modes that have not been coupled into the core mode couple into cladding modes.

Less is known about the wrapping configurations of the other binding modes, especially the (SSB 56 mode that has only been detected on long poly dT) ssDNA (Bujalowski and Lohman, 1986).

This result suggests that the most potent inhibitor in this series, compound 15, has a binding mode that is highly correlated with the conformation of naproxen inside COX-2 active site.

Among the various HU-nucleic acid binding properties that have been described, different DNA binding modes can be invoked to explain mechanistically its regulatory function.

This has revealed stable intermediate states of (dT 70 ssDNA wrapping around a single SSB tetramer that correlate well with the known [NaCl]-induced poly dT) binding modes, (SSB 65, (SSB 56, (SSB 35 that have been observed for SSB binding to longer poly dT) (Lohman and Overman, 1985; Bujalowski and Lohman, 1986).

This chapter surveys the various binding modes and the resulting structures that have been observed for the large number of different carboxylate ligands, which have been used in this chemistry.

This binding mode might correspond to transient cohesin-chromatin interactions that have previously been observed in D. melanogaster [ 37].

Recently, we discovered that an RNA-binding protein called Glorund uses a unique mode of interaction to bind and repress the translation of mRNAs that have not been correctly localized to the posterior of the egg.

This review surveys the large number of type II inhibitors that have been developed and provides an analysis of their crystallographically determined binding modes.