Your English writing platform
Discover LudwigSuggestions(4)
Exact(1)
To understand different binding modes that could underlie the observed difference in inhibition, we performed theoretical calculations of binding free energies in parallel with direct experimental measurements using ITC and structural analysis by X-ray crystallography.
Similar(58)
This radar also multiplexed a Beyond The Horizon (BTH) pulse mode that could complement the pulse-Doppler radar mode.
Thus, PriB binds to dsDNA via the RTP-binding mode that can be ruled out.
Molecular docking studies were carried out to investigate the mode of binding as well as important binding site interactions that could possibly explain the increased CA inhibition observed for chloro triazine derived compounds.
The infrared spectroscopies, theory calculations and the electrochemical impedance spectroscopies revealed that carboxylic acid anchoring binding modes could increase the efficiency of electron injection.
The highly modular domain organization of Rap1 and the observation that different regions participate in different functions of the protein (see the introductory section) suggest the possibility that the transition between binding modes could be regulated either internally by its other domains or externally through interactions with Rap1 interaction factors.
In the future, harnessing control over binding modes could offer new approaches to designing molecular assembly systems that achieve defined protein orientations.
The observed binding modes suggested that all three compounds bind at the ligand binding site of IL-2.
We assumed that a peptide with a certain sequence has one of those binding modes, and that the mode of the peptide with the lowest energy is the closest one to the natural binding mode of the sequence.
Thus, HLA-variants may bind drugs with drug-specific (or class-specific) peptides that could significantly enable, boost, and thus impact their binding modes.
To further define the Rab5−APPL1 binding mode, we performed extensive pull-down analyses between variants of Rab5 and APPL1, looking for reversal mutants that could rescue the lost binding ability of others.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com