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Essential revisions: 1) Some additional information in the Introduction to highlight the biological and biophysical significance of the cellulosome cohesin-dockerin interactions and in the Discussion to show the benefits of having two binding modes should be added.
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The obtained new PDK1 inhibitor and its PDK1-inhibitor binding mode should be valuable in future de novo design of novel, more potent and selective PDK1 inhibitors for future development of anticancer therapeutics.
Since α-Nrx uses the common LNS6 domain as its primary NL-binding site [31], its binding mode should be no different from that of β-Nrx.
Other repair modes should be considered.
According to this definition, the handoff latency of the RO mode should be the same as that of the BT mode because an MN will resume communication when it finishes the binding update to its HA.
Stereo Mode should be Joint Stereo.
The words "Safe Mode" should be constantly displayed if you have successfully booted in that mode.
Binary mode should be used for transferring the files.
This binding mode should provide more favourable binding to the molecular assembly.
The use of "alternative pockets" represents a new mode of high affinity peptide binding, that should be considered when predicting peptide epitopes for MHC class I.
Its binding site should be well characterized.
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