Sentence examples for binding modes in different from inspiring English sources

This is of importance because in a biological reality, a ligand might exhibit similar or different conformational binding modes in different complexes.

Thus, the rotational freedom within Raltegravir allows it to adopt a previously unappreciated bound conformation, highlighting that a drug can have distinct binding modes in subtly different molecular environments.

The structures reveal that AMPA agonists with an isoxazole moiety adopt different binding modes in the receptor, dependent on the substituents of the isoxazole.

These different binding modes in nNOS and eNOS, caused by the Tyr residue mobility, have proven to be the basis for the sharp differences in inhibitor potency (Table 1).

We also compare a preliminary prediction for 5-HT2B with our prediction for 5-HT2C and find a difference in TM5 that contributes to different serotonin binding modes in 5-HT2B and 5-HT2C.

Different ATP binding modes in ELK groups.

The analysis of this superfamily also provides new data to investigate the evolution of carbohydrate binding modes in β-sandwich domains with very different topologies.

The results evidently reveal the versatility of 3-bpt with different configurations and binding modes in coordination assemblies, which will be profoundly influenced by the metal ions and even inorganic counter anions.

Each has unique binding modes resulting in different ER conformations [ 3], binding affinities [ 59, 60], ligand-induced binding domain topographies [ 61], coactivator recruitment capabilities [ 62, 63], gene-specific thresholds of activation, and efficacies [ 64].

Various binding modes requiring different DBDs in the trimeric RPA have been presented [ 3, 22– 25].

When introducing the excluded volumes of the new D1 pharmacophore model we discovered that the D1 agonists may bind in two distinct binding modes involving two different receptor binding site conformations.