Sentence examples for binding modes for two from inspiring English sources

Since chooseLD inferred suitable binding modes for two potential ligands, we concluded that in silico drug discovery is possible for TINAGL1, which might be a promising candidate drug target.

Obviously, the indole system is larger than a simple phenyl ring, something that would clearly affect the binding modes for the two different series at the orthosteric site.

Comparison of all variant activities on each substrate indicated different binding modes for the three aromatic substrates, supported by computational docking.

In many aspects, the binding mode for the two isoforms, HDAC1 and HDAC6, is very similar.

This correlates well with a similar effect in CD38 for 8-NH2-cIDPR vs. cIDPR, recently observed crystallographically in an 8-NH2-cIDPR CD38 8-NH2-cIDPR CD38 8-NH2-cIDPR CD38ies a likely similar binding mode for the two types of analogue, supporting the overall complex oFigyrophosphate replacement.

From these structures and a saccharide-binding analysis of the N46A mutant, we revealed that a conformational change of a unique insertion sequence containing Asn46 provides two binding modes for ACG, and thereby confers broad binding specificity.

The binding data best fit to a 2 1 binding model, suggesting two binding modes for S20 on HA.

The subunits pack in head-to-tail orientation, leading to a symmetric binding cavity, reflected in two binding modes for the bound ligands in several cases.

Two major binding modes for the SSB−DNA interaction have been described.

31 The geometrical differences in TM6 and TM7 between D1 and D2 may be the reason why we see two different binding modes for D1 agonists and only one for D2 agonists.

Relevant binding modes for CYP6BQ11-Pyr were found for all four insecticides suggesting an association with resistance to all four insecticides (see Additional file 7).