Sentence examples for binding modes could be from inspiring English sources
The understanding of the binding modes could be advantageous for further development of selective ligands for the CB2 receptor.
A sequence comparison of the ETA and ETB receptors showed that the residues that interact with the common moieties between bosentan and K-8794 are highly conserved, which suggests that their binding modes could be essentially similar in the ETA receptor (Fig. 3f and Supplementary Fig. 5).
The highly modular domain organization of Rap1 and the observation that different regions participate in different functions of the protein (see the introductory section) suggest the possibility that the transition between binding modes could be regulated either internally by its other domains or externally through interactions with Rap1 interaction factors.
Such a binding mode could be suggestive of modulation or inhibition of channel activity of host RBCs.
The active site architecture was similar to the wild-type, even an identical substrate-binding-mode could be observed [24].
This is indicative of a change in binding mode or could be due to the phenyl ring in C12M02 occupying a new high affinity binding pocket.
The Zn-binding mode could well be the evolutionarily older one in this protein.
In such an environment, a dual binding mode could enable organisms to produce enzymes that are able to bind to a neighboring species' scaffoldins, yet still retain high-affinity interactions with host scaffoldins.
The dual binding mode could therefore allow genetic drift to explore interspecies protein binding.
This supports the hypothesis that the binding mode of CK157 could be similar to that of vCKBPs, where a large negatively charged area engages conserved GAG-binding regions on CC and CXC chemokine proteins, thus explaining their extensive promiscuity (Supplementary Fig. 13b).
