Sentence examples for binding modes but also from inspiring English sources

We now provide confirmatory experimental evidence to not only rule out the earlier ligand binding modes but also the proposed catalytic mechanism.

When we analysed the binding modes of the H3 peptides, we observed not only that the peptides adopt a similar binding mode but also that they form similar interactions with several receptor residues.

With these additional analyses and data, we unequivocally rule out the earlier structural model both statistically and experimentally not only in terms of ligand binding mode but also in terms of the proposed catalytic mechanism.

When docking was performed without co-binding peptide, abacavir was observed in two stable binding modes, but when peptide was included in the docking procedure, there was only one stable binding mode remaining [44].

It is important to note that other interactions with DNA bases showing non-classical binding modes are also physically possible, but less common (Siggers et al., 2005; Wolfe et al., 2000).

These proposed binding modes are also proved by 1H NMR titration.

Variability in SAG-TCR binding modes could also contribute to the structural heterogeneity of SAG-dependent signaling complexes.

Comparison of the results obtained from the titration of the disulfide-reduced and disulfide-intact chimeric peptide with various sulfated oligosaccharides, derived from heparin, suggest that the initial structure of the peptide has pronounced effect on the binding affinity, binding modes and also on binding preferences.

The N-terminus of the ligand peptide are thought to insert into the orthosteric binding cavity, although alternative binding modes are also proposed (Beinborn, 2006).

In the presented work various protein-ligand complexes have been studied where the tautomeric states of the ligand have a significant impact on derived 3D pharmacophores and the perception of binding modes, and also, tautomer-invariant pharmacophore patterns are introduced.

Common predicted binding modes can also be observed for the synthesized compounds against the adenosine receptors A2AR and A1R. Figure 3 displays the interactions of two representative compounds 18 and 25, which exhibit Ki values of 948 and 55 nM respectively, and these are H-bonding of their pyridine rings with Asn253 and π-stacking of their amino and carbonitrile groups with Phe168 of A2AR.