Sentence examples for binding modes and also from inspiring English sources
In the presented work various protein-ligand complexes have been studied where the tautomeric states of the ligand have a significant impact on derived 3D pharmacophores and the perception of binding modes, and also, tautomer-invariant pharmacophore patterns are introduced.
Comparison of the results obtained from the titration of the disulfide-reduced and disulfide-intact chimeric peptide with various sulfated oligosaccharides, derived from heparin, suggest that the initial structure of the peptide has pronounced effect on the binding affinity, binding modes and also on binding preferences.
We have now included the additional data and discussed the ZF and bHLH cases, and the features of the computational analysis pipeline in the second paragraph of the Results section and in the beginning of the subsection headed "Identification of secondary binding modes and dinucleotide preferences", also in the Results, respectively.
10.7554/eLife.08193.016 Figure 4. SSB binding modes and diffusion mechanism.
We refer to this binding difference as distinct binding modes, and suggest that the different transcriptional outcomes are related to the binding modes.
Computational methods: Information on the homology model used to predict the binding mode and ligand docking methods is also given in the Supporting Information.
The results suggested that the ligands and Zn II) complexes bind to DNA via intercalative binding mode, and their binding affinity for DNA are also different.
Crystallographic evidence of binding mode and in vivo potency data is also highlighted.
We will also show here that special care has to be taken when one wants to use this vast amount of information, because there is a lot of noise (non-active compounds) and the data include protein targets with multiple binding sites or modes, and also some classes based on organisms rather than on proteins.
The binding mode and effect of N-substituent groups were also investigated.
The crystallographic and docking studies also suggest that the aryl compounds prefer the forward binding mode and the flurorenyl analogs orient in a reverse binding mode.
