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The performance was assessed directly by visual inspection of the PET data and indirectly by assessing the inter-subject variability in baseline BPND, convergence and residuals of the competitive binding modelling and the drug EC50 estimation.
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Binding data were fitted to a simple 1 1 binding model.
Binding curves were fitted to a single-site binding model to estimate KD.
Binding was analyzed with BIAevaluation software (Biacore) using a 1 1 binding model.
Fitting was performed using a single-site binding model.
The corresponding tight binding model is also constructed.
Motor primitives, entrainment, locomotion, active sensing, binding models.
For GR DBD binding to κBREs, a two-site binding model was used.
CSP titration curves were fitted using the one-site binding model.
A global fit according to a 1 1 binding model was applied (black dashed curves).
Thermodynamic data were analyzed with a single-site binding model using MicroCal PEAQ-ITC Analysis Software provided by the manufacturer.
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