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All binding values are the result of fitting titration data to a 1 : 1 binding model, which is consistent with Job's method of continuous variation.
The relatively high degree of flexibility within the L2 region may be a prerequisite for specific Hb binding to IsdBN1, supporting a "folding upon binding" model which is often observed for intrinsically disordered regions of proteins, and the plasticity of Hb-binding NEAT domain architectures.
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Dashed lines are fittings via one site total binding model, which was also used to estimate KD values (GraphPad Prism).
The emphasis is put on a general introduction to site binding models, which are able to account for many experimental features of linear and branched polyelectrolytes, including dendrimers.
The second major conclusion was that the sequential model predicted weaker and more variable Ly49-MHC class I bindings compared to the two-step selection model, which was reflected by the fact that the number of predictions of sufficient strength to pass selection ("suff") was 21 for the two-step selection model and only 9 for the sequential model.
The largest publicly available databases of TF binding specificities contain models which are represented as position weight matrices (PWM).
no models which are headed for discontinuation.
Docking simulation was performed to position compound 4q into the colchicine binding site to determine the probable binding model, which suggested probable inhibition mechanism.
The chapter discusses various types and families of models, from the models of humic structure, which tend to be conceptual, to the various metal binding models, which tend to be more mathematical.
Our calculations are based on the tight-binding model, which the recursive Green's function method is used to solve inhomogeneous differential equations.
Troponin C has a lower amount of binding sites, which is modeled as a lower concentration.
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