Sentence examples for binding model where the from inspiring English sources

These studies provided the binding model where the carbonyl group at position 27, the hydroxyl group at position 30, and the phenolic hydroxyl group at position 20 of ATX were involved in intermolecular hydrogen bonding with the PKCδ C1B domain, which would be useful for the rational design of ATX derivatives as anticancer lead compounds.

The scaling factor accounts for the fact that in the competitive binding model the nonannular site will be fully occupied by lipid B at a mole fraction xB of 1, whereas this will not be true in the simple binding model where the site might be only partially filled, depending on the value of K2.

Our results suggest that if the measured bound fractions are kinetically limited, they will still monotonically increase with concentration and may even be satisfactorily fitted with impostor equilibrium binding models where the isotherm midpoint is shifted to higher concentrations.

The κ-Al2O3 phase itself is metastable up to 1000 K. To test the robustness of our materials-theory prediction of the 1DEG along the zigzag Al lines, the critical temperature due to a Peierls metal insulator instability has been estimated to be in the temperature range [0,1] K, using a tight-binding model, where the model parameters are determined with additional DFT calculations.

The resulting equation (eq 6) (procedures of the Supporting Information) was used to globally fit this binding model where n is the number of identical sites (three).

Three dimensional structural studies of ZFPs have given insights on the ZFP-DNA- binding interface and it can be compared with respect to a 'canonical binding model' where each finger interacts with DNA in an anti-parallel mode.

Studies have suggested a cooperative model where the binding of one SEA to MHC class II favors the binding of the second SEA molecule [13], [17], [18], and MHC class II - (SEA 2 trimers have been isolated in solution [18].

This observation supports a model where the binding of the homologous GTPase domains of SRP54 and the α-subunit of the SRP receptor to each other regulates the release of ER signal sequences from the SRP54 M-domain.

Here, we show that the decoding bases flip on a timescale faster than that of gentamicin binding, supporting a stochastic gating mechanism for antibiotic binding, rather than an induced-fit model where the bases only flip in the presence of a ligand.

These data support a kinetic proofreading model where the principle binding parameter controlling T cell activation is the TCR off-rate or mean dwell-time.

Free energy of binding was calculated using a previously reported model, where the substrate analogue 5′-CCA-Ala was docked into the isolated INS domain (residues 242 388) of Ef ProRS.