Sentence examples for binding model of ligands from inspiring English sources

The small molecular activator that we recently discovered, ztz240, was used as a probe for determining the binding model of ligands in the gating charge pathway.

(4) The heat capacity changes (Δ C p °) associated with the binding of the different SAHA analogues to HDAC8 cannot be rationalized in view of the classical hydrophobic binding model of the enzyme ligand complexes.

We report how computational modelling predicted the binding mode of ligands of special interest to the Chk1 ATP site, for representatives of an indazole series and debromohymenialdisine.

Binding models of selected ligands in the carbohydrate-binding site of OsEULD2.

Binding models of selected ligands in the carbohydrate-binding site of OsEULS3.

Fig. 4 Binding models of selected ligands in the carbohydrate-binding site of OsEULS2 and OsEULD1A.

The data were described using a one-site ligand binding model, with a ligand concentration of 0.19 μmol site mg−1 C, and a log K′ of 6.2.

Finally, in the third model, binding of ligand may lead to the movement of the receptor complex to a subcellular compartment (e.g. a subdomain of the plasma membrane or an early endosomal compartment) where the complex is exposed to the modifying enzymes.

For example, Wittwer et al. developed a quantitative structure-activity relationship (QSAR) model of ligand binding to the multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) by experimental high-throughput screening (HTS) for drug libraries.

In support of their model of ligand binding, only receptors possessing both aspartate residues are activated by diamine ligands.

If this general model of ligand binding is correct, the implications for structure-based drug design are profound, as the same principle of binding likely applies to many other systems as well.