Sentence examples for binding mode which forms from inspiring English sources
A novel inverse binding mode, which forms the basis for the improved selectivity, was suggested by molecular modeling and confirmed by determining the crystal structure of DYRK2 in complex with 6i.
The active molecule 3c could effectively interact with S. aureus DNA to form 3c DNA complex through groove binding mode, which might block DNA replication to display their powerful antimicrobial activity.
A subsequently determined structure of Sorafenib with c-Raf revealed an overall similar binding mode, which was termed a 'type II' binding mode.
AC-D employs an entirely novel binding mode, which differs from the amphipathic helix method used by many transcriptional activators.
Taking into account the aforementioned findings, we assessed that, among diverse calixpyrroles derivatives, the C4PY binding modes (which describes the orientations of the ligand and receptor, and the conformation of each when they are bound) to GPER are mainly characterized by a network of hydrophobic interactions formed between the macrocycle rings and the protein core residues.
Molecular modelling study revealed different binding modes which might underlie the observed opposing biological activities.
Interestingly, the indirubin E804 complex exhibits two binding modes which can be explained by the near-symmetrical core scaffold.
The latter points to distinctly different stable binding modes, which terminate at different locations in the G31−L100 segment.
The results indicate a convergent and complementary 1 1 binding mode, in which a BiPy ligand binds to a host molecule by ditopic ZnN coordination forming a stable cyclic supramolecular complex.
These conformations are involved in a new "half open" binding mode in which a benzene molecule lodges in a smaller cleft formed by five of the hydrophobic pocket residues: Val415, Tyr417, Tyr481, Phe482 and Tyr485.
Therefore this binding appears to require multiple sites to be phosphorylated, suggesting a binding mode in which multiple phosphoepitopes engage a single receptor site in dynamic equilibrium.
