Sentence examples for binding mode to that from inspiring English sources

Docking study performed for 8a with ATP binding site of EGFR-TK showed the similar binding mode to that of AZD9291.

In addition, computational predictions of the fitting of saponins to the topoisomerase I DNA complex, indicate a similar binding mode to that of clinically used topoisomerase I inhibitors.

While in Fig. 4b shows the binding mode of the co-complexed ligand 5XG and 5-fluorouracil (the standard inhibitor of cancer) is having a different binding mode to that of the four active compounds of bis-pyrimidine Schiff bases.

The interaction of mPD-1 with mPD-L2 reveals a similar binding mode to that with PD-L1, which also involves both of the IgV domains with the front β sheet faces interacting with each other (Fig. 1B) (Lazar-Molnar et al., 2008).

The crystal structure of 14d bound to Aurora-A 22,24,25 (Fig. 5, Table S3, Supplementary data) shows a similar binding mode to that adopted by 7a; however, the P-loop of Aurora-A adopts a different conformation, stabilised by interactions with the 5-methylisoxazole; this P-loop conformation is very similar to that previously observed for compound 1 (compound 51 in Ref. 10).

It is also possible to explore novel binding modes, to look for compounds that interact with the target receptor in ways that are not seen with existing known ligands.

One compound, mS-11, binds strongly to mSin3 with a binding mode similar to that of NRSF/REST.

We reasoned that if a binding mode similar to that observed in the Pdar Prb interaction is utilized, mutation of these residues might result in new proteins that selectively recognize gankyrin.

Further, molecular docking studies suggest that 30n has binding mode similar to that of LNZ in 50S RNA ribosome.

In these two structures, one of the three nitro groups of the substrate is always stabilized between residues corresponding to H178 and N181 in NerA, in a binding mode similar to that observed here.

Such a change in the binding mode relative to that of the parent aptamer might also contribute to the apparent decrease in binding affinity.