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Exact(3)
In addition, the binding mode suggests that extensive hydrophobic interactions are formed between SC7 and hydrophobic region (R1 region in Fig. 7) near the residues Pro535 and Leu536.
This CA binding mode suggests that NP polyamines may have potential to provide additional CA inhibitors with this altered mechanism of binding and inhibition of CAs.
Analysis of available structures together with the predicted D-captopril binding mode suggests that this difference may reflect more substantial ligand-binding induced movement of the L1 loop in the case of D-captopril.
Similar(57)
This binding mode suggested that 7 and SAHA should display similar potencies as HDACis.
Comparison of the different binding modes suggests that avoiding the deep insertion of inhibitors into the transmembrane helix bundle may be able to preserve chemokine-CCR5 interactions.
The observed binding modes suggested that all three compounds bind at the ligand binding site of IL-2.
Furthermore, the predicted binding modes suggest that the backbone carbonyl of Y6.48 forms an interaction with T32 (in OxA) and T27 (in OxB).
But the inconsistency in the low energy binding modes suggests nonspecificity.
This coordination mode suggests that Fe2 is the preferred iron for substrate binding.
The observation of compact modes suggests that strong binding, associated to small dissociation rates, is not required to ensure high occupancy.
This is consistent with the AUC measurements, which also confirm that a low salt concentration favors 35-base binding mode and suggests that the higher affinity of the complex is at least in part due to faster association of the second SSB.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com