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One compound, mS-11, binds strongly to mSin3 with a binding mode similar to that of NRSF/REST.
Based on the co-crystal structure, Zanotti et al. have shown that all-trans-retinoic acid, a cyclohexene-linker-acid compound, binds to TTR in a forward binding mode similar to thyroxine [30].
Further, molecular docking studies suggest that 30n has binding mode similar to that of LNZ in 50S RNA ribosome.
Besides targeting cyclooxygenase, indomethacin also inhibits PTGR2 with a binding mode similar to that of 15-keto-PGE2.
The most active compound 11e (IC50 = 2.5 μM) was selected for molecular modeling studies and showed a binding mode similar to the one of the known LEDGIN 8.
Docking studies reveal that these compounds showed a binding mode similar to those observed with their non-constraint isoCA-4 and isoerianin congeners.
Similar(43)
Docking study indicated that the new inhibitors assumed binding modes similar to that of Ertiprotafib.
This list should contain rice proteins that are related to CaM or has functions based on Ca2+-binding mode similar to CaM.
Analysis of naproxen inside the COX-2 active site (PDB entry 3NT1) indicates a binding mode similar from the one of indomethacin.
To understand their mechanism of action, tubulin binding assays were performed which pointed to their binding to microtubules in a mode similar to but not identical to colchicine, as evidenced by their KD value evaluation.
Consequently, binding in modes similar to one or two is highly unlikely, as this would disrupt the hydrogen-bonding interactions from N1.
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