Sentence examples for binding mode provides a from inspiring English sources

An examination of whether the binding mode provides a foundation for the ability of Srs2ΔC to unwind various DNA substrates revealed similar unwinding efficiencies for the majority of substrates, including the fork, 3′ flap, 5′ flap, and Y-form.

The top 15 ranked structures were found to conform to a similar binding mode, providing a high degree of confidence in the general locus and conformation.

Knowledge of the atomic interactions involved in these diverse binding modes provides a platform for structure-guided modification of these compounds, or the de novo design of novel inhibitors that could satisfy the need for potency and selectivity.

The characterization of hits (at a pharmacophore level or from determination of their exact structural-binding mode) provides insights into the structural determinants for ligand recognition, the probable structural characteristics of endogenous substrate(s), and hence insight into the functional role of the enzyme.

In this work, we have used a pre-existing classification of protein protein binding modes provided by SCOPPI.

These active compounds and their binding modes provide useful information for understanding the molecular mechanism of reversible MP inhibition.

Thus, the p7 allosteric site can be targeted by structurally diverse molecules with variable binding modes, providing considerable scope for future drug discovery.

Our structures provide the first pair of structures where an identical PPR protein compacts upon binding a nucleic acid in the canonical, sequence-specific mode, providing an opportunity to understand how the conformation of the protein changes upon ligand binding.

Compound optimization was guided by X-ray crystallography of representative examples bound to the yeast 20S core particle, which established their non-covalent binding mode and provided a structural basis for potency-enhancing modifications.

Compound optimization, guided by X-ray crystallography of the liganded 20S core particle, confirmed their non-covalent binding mode and provided a structural basis for their enhanced in vitro and cellular potencies.

The obtained results, along with a 3D-QSAR study and molecular docking that were used for investigating the probable binding mode, could provide an important basis for further optimization of compound 6f as a novel anticancer agent.