Sentence examples for binding mode of such from inspiring English sources

Although most of the drugs commercially available have emerged through conventional drug discovery methods such as high-throughput screening (HTS), computational methods and functional assays, it is the structural information provided by the three-dimensional (3D) atomic structures that discloses details regarding the binding mode of such proteins.

These docking calculations coupled with HINT interaction analyses are able to represent the complex structures and the binding modes of inhibitors such that calculated and measured free energies of binding correlate with an r2 of 0.76.

In combination with functional studies and molecular modeling, the structure provides insight into the binding mode of naturally occurring CB1 ligands, such as THC, and synthetic cannabinoids.

However, a close inspection of their models revealed that such binding mode of P1-His requires structural changes of the backbone atoms of the P1 residue.

As such, it helps to get a better understanding of the binding mode of an inhibitor.

CHIR-090 shares a similar, although previously unrecognized, chemical scaffold with other small-molecule antibiotics such as L-161,240 targeting LpxC, and provides a template for understanding the binding mode of these inhibitors.

Since the pattern of arising BCR-ABL mutants should be associated with the binding mode of that particular compound to the Abl protein, conceptually, the greatest benefit from a combination of two such agents should be achieved using compounds having the greatest difference between their binding modes.

a, Possible binding mode of CoA in the CoA domain.

This suggests that its binding mode mimics the true binding mode of the distal phosphate group of PPi because the sulfate ion has no methylene group.

Baumgartner, R. et al. Dual binding mode of a novel series of DHODH inhibitors.

(a) 3D and (b) 2D representation of the predicted binding mode of quinine at ggTas2r1 receptor.