Sentence examples for binding mode is the from inspiring English sources
A significant difference with the E2 binding mode is the loss of two H-bonds to Arg394 and His524, which are partly compensated by novel interactions to Leu346 (H-bond to the backbone oxygen atom) and His524 (aromatic interaction).
Our modeling studies and thermodynamic calculations confirmed that this binding mode is the only feasible one in PEDH.
The details of the reaction mechanism are still not completely defined, and so one has to make the hypothesis that the observed binding mode is the relevant one.
1) The details of the reaction mechanism are still not completely defined, and so one has to make the hypothesis that the observed binding mode is the relevant one.
The correct binding mode is the second largest cluster, which has a −6.8 kcal mol−1 free energy of binding and comprises 10% of all the possible docking conformations.
We propose that in solution, one possible path leading to the transition between the two binding modes is the transient opening of the C-terminal wrapping loop.
For two of them we have determined their crystal structures by X-ray diffraction and we have found that in the solid when the ancilliary ligand is bpy the N-binding mode is the most stable, while dmb is the ligand, the –CH3 substituents imposed the C H (methyl group)⋯O NO (nitrito) interactions favoring the O-binding mode.
The dynamic binding mode is thought to be the result of continuous cohesin loading and release reactions, mediated by the loading complex and Wapl, respectively, and has been proposed to contribute to chromatin organization and gene regulation [ 12, 15].
The first binding mode is adopted by the H3 peptides, whereas the other mode is adopted by the H4 peptides.
At high salt concentrations, this effect is much less apparent as the SSB 35) binding mode is destabilized and the protein switches to the SSB 70) binding mode without inter-tetramer positive cooperativity (Lohman and Bujalowski, 1988; Lohman and Ferrari, 1994).
The inhibitor binding mode is novel, with the cyclopropanecarboxylic acid moiety directed towards the solvent exposed region of the ATP-binding pocket, and several induced structural changes in the active-site compared with other published AIK structures.
