Sentence examples for binding mode in which from inspiring English sources

The results indicate a convergent and complementary 1 1 binding mode, in which a BiPy ligand binds to a host molecule by ditopic ZnN coordination forming a stable cyclic supramolecular complex.

The data were better in agreement with a binding mode in which substituents protrude along the interfacial cleft of the receptor.

We present a binding mode in which one terminal phosphoryl oxygen atom as well as the nucleophilic group (hydroxyl anion) binds to zinc center.

To perceive the exact mode of binding of these ligands, two models of the ligand EGFR complexes were considered: (1) reversible binding mode in which the ligand had hydrogen bond interactions at the binding site and (2) irreversible binding mode wherein the ligand's Michael acceptor side chain has proximity to the sulfhydryl group of C773 of EGFR, thereby enabling a covalent interaction.

Therefore this binding appears to require multiple sites to be phosphorylated, suggesting a binding mode in which multiple phosphoepitopes engage a single receptor site in dynamic equilibrium.

These observations allows to hypothesize a binding mode in which the multiple sites found in Sirt-1 might engage the putative receptor sites of AROS (5 Ser and 4 Thr residues) in a dynamic equilibrium.

Molecular docking studies were also performed on human AChE and BuChE to suggest possible binding modes in which the inhibitor's extended structure is accommodated along the active site gorge of both enzymes.

The five top ranked solutions for Model B (one from each independent docking run) were found to possess similar binding modes, in which the N-terminus adopts a disordered conformation, with a stretch of seven residues, 10TLTIIKT16, loosely engaging the hydrophobic groove of the DRS of ERK2 (Fig. 3A).

The structural data reveal a variety of binding modes in which hydrophobic residues on helix-6 and helix-7, including M199, I202, V203, L207, and I215, explore different modes of interaction with the inhibitor as well as with other structural elements from the enzyme itself.

Our crystal structure showed one metal binding mode in GI, which we presumed to represent the inactive form of the GI.

The results evidently reveal the versatility of 3-bpt with different configurations and binding modes in coordination assemblies, which will be profoundly influenced by the metal ions and even inorganic counter anions.