Sentence examples for binding mode compared to from inspiring English sources

Naproxen is another reference inhibitor that is stabilized in the active site of COX-2 with a different binding mode compared to indomethacin.

Thus, it is worth to investigate this series using a reference such as naproxen that has different binding mode compared to indomethacin.

Somewhat unexpectedly, these two compounds docked in a reverse binding mode compared to CA II: in CA XII the benzothiazole ring of these ligands is flipped).

To render support to the experimental results, a series of quinazolinone derivatives were docked into active site of ACE and identified the probable binding modes compared to Lisinopril.

This is an entirely new binding mode compared with the canonical binding modes found in some transcriptional activators or repressors, in which an intrinsically disordered region (Dyson and Wright, 2002) of each activation or repression domain binds to a target protein with part of the flexible region forming an ordered structure upon binding to the target.

This requirement is much better met in CBA mode compared to the BA mode.

When docking with P3, the most dissimilar binding mode, when compared to abacavir, was DB08048 (an experimental drug) with a TIF similarity of 0.55.

Here, we report site-directed mutagenesis of MftR, which reveals a differential mode of ligand binding compared to that of previously characterized UrtR homologues.

An incompatibility arises whenever the fitness of the hybrid is − ∞ [ h 12 > r   * or h 21 > r   * ], i.e., when a hybrid TF TFBS specific binding is weak compared to the nonspecific mode of binding and effectively can no longer recognize its target site.

There were more features detected in the ESI- mode (1,900) compared to ESI+ mode (1,478).

The crystal structure of FED1 shows a binding mode similar to EPZ004777, with the tert-butyl phenyl urea motif further extending the binding pocket compared to SAM.