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By these definitions we model a binding mechanism in a Markov logic network and define its role in a cognitive architecture.
The combined four mutations F151S, A152S, F714S, F717S are therefore sufficient to hinder the binding of CaM to hEAG1 (p>0.05) BD-C1 and other auxiliary sites can still be involved in the binding mechanism in a cooperative manner.
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A two-step binding mechanism in which a faster transient developed at the higher concentrations of 2-OG assayed was identified.
Importantly, the relationship between lignin and enzymatic binding (Fig. 7a) indicates a competitive binding mechanism, in which both enzyme and inhibitor (lignin) bind favorably to the substrate (cellulose).
These results suggest a conserved lipid binding mechanism in which Ca2+-independent interactions are mediated via a lysine rich region of the C2B domain while Ca2+-dependent interactions are mediated via the Ca2+-binding loops.
These observations thus argue against a cooperative binding mechanism in the tandem UIMs binding with Ub.
Although a multisite binding mechanism in mutants is retained, the enzyme is exquisitely sensitive to the minor structural changes in the binding pocket introduced by the point mutations S119A, I369F, I369L, A370L, and A370V.
To obtain a more accurate description of the binding mechanism, in addition to the unconstrained target genes shared by a set of TFs, also mutual targets were considered that allowed for colocalization of the TFs.
Despite the retention of the multisite binding mechanism in the mutants, functional manifestations reveal an exquisite sensitivity to even minor structural changes in the binding pocket that are introduced by conservative substitutions such as I369F, I369L, and A370V.
The potentials that result from interactions involving multiple domains generate a novel, modular binding mechanism in which opposed cadherin ectodomains can adhere in any of three antiparallel alignments.
Structure homology modelling recovered the conserved structure between the SjIRs and Homo sapiens IR (HIR) implying a common predicted binding mechanism in the ligand domain and the same downstream signal transduction processing in the tyrosine kinase domain as in HIR.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com