It is, therefore, conceivable that this downstream binding may reflect an additional function of the Tip60 complex that may play a role in the early steps of transcription elongation processes, as suggested also in Drosophila [ 45].
Most de novo GATA2 peaks display weak binding of GATA1 (not shown); thus, de novo GATA2E binding may reflect an intermediate stage of the erythroid program, where sites that are not primed by GATA2 in MPCs sequentially bind GATA2 and then GATA1 as their expression increases during differentiation.
The competition between GADD34 and TRAF6 for Akt binding may reflect a regulatory system that maintains cellular homeostasis in response to stressors such as TBI.
The discrepancy between RBf protein binding and E2F factor binding may reflect the two different developmental stages used for measuring binding, although many individual genes are similarly bound in both stages (Acharya et al. 2012; Korenjak et al. 2012).
It can be conjectured that the presence of genes, which have lost (or not still acquired) the binding sites, may reflect a relatively recent evolutionary divergence, such as is expected among strains of the same species and confirmed in the case of nolR, whose inactivation in the laboratory strain Rm1021 probably happened recently, since even its DNA-binding sites are conserved.
First, in the absence of the modified peptide, a peptide N-terminal to RAG2-PHD occupies the substrate-binding site, which may reflect an autoregulatory mechanism.
The importance of predominant cytoplasmic staining in oesophageal cancer remains to be determined, but may reflect an increased binding of cytoplasmic Hsp90 client proteins.
Enhanced dissociation on 2 molecules of adenosine binding to an A3-AR homodimer may reflect an additional physiological mechanism to reduce the residence time of the endogenous adenosine at pathophysiologically high concentrations.
In this experiment the PRH N187A appears to immunoprecipitate much more TLE than the corresponding wild-type PRH protein, which may reflect an increased binding affinity between PRH N187A and TLE proteins.
This lack of enhancement may reflect an absence of a citral activation binding site, or saturation of a common binding site by menthol (30 µM), 4α-phorbol-12, 13-didecanoate (10 µM), and allyl isothiocyanate (300 µM), respectively.
The favourable entropic component of binding of the lead series may reflect a disordered binding mode and may explain the difficulties in obtaining a crystal structure in complex with the protein.
