This intramolecular binding may prevent binding to α-adaptin and, as a result inhibit recruitment of Eps15 to the coated pit, which may cause the inhibition of EGFR endocytosis.
Transcription factor binding may prevent DNA methylation at these sequences, while diminished binding may result in de novo DNA methylation [ 18].
In contrast, we found that gctBid did co-precipitate with Bcl-2 in cells treated with Pfp/GraB alone, so this binding may prevent gctBid from activating Bax or Bak.
Thus, the binding of IncE may prevent the recruitment of the CI-MPR cargo molecule by the retromer.
Such PAMP-binding may prevent induction of plant basal defense responses.
Additionally, binding of Npl3 to the RNA may prevent the formation of arrest-inducing secondary structures, or suppress pausing at cryptic polyA sites.
Alternatively, the deletion of the C-terminal tail may prevent the COPII binding to other ER-exit signals, such as the MELADL-like motif in the Loop 6 region.
Thus, binding of cytosolic Ca2+ by BAPTA-AM may prevent the activation of S100 proteins, which consequently may lead to an amplification of Hael-induced growth arrest and apoptosis.
However, it should be noted that the consensus ERE sequence of the porcine ELOVL6 promoter, contains SNP ELOVL6 c.-394G > A, which constitutes a third mutation in the half-site of the ERE palindrome that may prevent the ER-ERE binding [52].
Whether the ability of K11-polyUb linkages to stabilize proteins is due to the topology of the chains, which may prevent the I44 Ub-binding surface from being exposed, or recognition of K11 linkages by as yet unknown K11-selective binding proteins remains to be determined.
