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On the other hand, we hypothesize that the conserved Phe, believed to stabilize the native conformation of the kinase catalytic site for ATP binding, may play the same role upon HSF-1 or L803 binding.
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This selective binding may play a role in the delivery of this protein to the plasma membrane [51].
This binding may play an important role in the HEV life cycle.
Halide binding may play a particularly important role in the highly regioselective halogenation reactions catalyzed by flavin-dependent, non-heme iron-dependent, and nucleophilic halogenases.
The deregulation of Nrf2-Keap1 binding may play a role in autophagy-related pathologic conditions as it was shown in mice in which loss of Nrf2 decreased but loss of Keap1 intensified the liver injury observed in autophagy-deficient mice.
Lead compounds were modified to investigate the possible role that zinc binding may play in inhibitor efficacy.
In the response to bacteria which elicit a largely IgG2 response, such as Streptococcus pneumoniae, FcγRIIA-H131 is most effective in binding the IgG isotype (14) and will be most important in binding the opsonized pathogen, whereas FcγRIIIB binding may play a lesser role.
This result indicated that genes in the categories of metabolic process, membrane, and cation binding may play crucial roles in responses to low-K+ stress in both rice and Arabidopsis.
CKIδ's ability to reduce XDsh/XDpr1a binding may play a part in Wnt's localization of XDsh and XDpr1a to disparate locations.
We therefore hypothesised that CTCF binding may play a role in regulating ER gene transcription by preventing transcription of estrogen target genes in the presence of tamoxifen.
E309 is located at the bottom of the substrate-binding cavity, and may play the same critical protonation-deprotonation role as D34 in ecMdfA.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com