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Although recent studies indicate that UCN-01 binds to the human serum protein alpha1-acid glycoprotein and that this binding may hamper the ability of UCN-01 to inhibit cell proliferation and kill cells in vivo, UCN-01 has decent activity against several tumours at dose levels that are tolerated in clinical studies [ 27, 28].
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Our results may indicate a threshold effect, since there is no discernible decrease in birth weight below a maternal PCB concentration of less than 25 μg / L. Assuming an endocrine mode of interference of PCB, a threshold effect is plausible since PCB may hamper the binding of hormones to their receptors [ 52].
The methionine filter removes combinations with epitopes containing methionine (symbol M ), since chemical modifications of methionine may hamper the recognition of the target epitope by a binding molecule, especially by an antibody.
Thus, SPN may hamper the autophagy phenotype.
However, some factors may hamper the testing of such systems.
Helping specific sustainable applications may hamper the level playing field of competing applications.
This may hamper the formation of a unified national market for commodities and laborers.
This may hamper the implementation as a single radio frequency integrated circuit (RFIC).
This "brutal reduction" may hamper the quality of French research, the committee warns.
The Ukrainian government's apparent inability to secure the paintings may hamper the agreement's passage.
The presence of hepatitis D virus may hamper the eradication of HBV.
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