Sentence examples for binding may explain the from inspiring English sources
While USP Ub binding may explain the weak activity of this enzyme class against poly-phosphoUb, the outlier USP21 shows that subtle differences in the binding site apparently enable a USP domain to target phosphorylated chains (Supplementary Fig S14A).
This important non-beta cell binding may explain the modest decrease in DTBZ uptake observed in long-term type 1 diabetic patients and in rodent models of the disease.
The effects of AD on U2AF65 binding may explain the strong dependence of TOES activity on the site of annealing within the exon (Owen et al., 2011), even though on its own it has only a very small effect on splicing even in the presence of the central ESE.
Additionally, hydrogen bonds formed by exocyclic oxygens of the cyclic phosphate moiety combined with the observed conformational changes in the PBC associated with cGMP binding may explain previous observations that (Rp -cGMPS oRp -cGMPSMPS analorueSp -cGMPS act aSp -cGMPSanaloguesof antagonists of PKG I.
Thus the combination of decreased CyP-D-binding affinity, increased partitioning into membrane phospholipids, and unspecific binding may explain why more mtCsA than CsA was needed to inhibit the PT pore.
In contrast, disruption of GTPCH-GFRP binding may explain phosphorylation-dependent upregulation of GTPCH activity in response to endothelial shear stress [ 28, 29].
Proximity of interdomain contacts to the binding pockets may explain the observed coupling between conformation and binding.
This complex binding mode may explain the lower than expected significance of SMAP hits for known H3P targets, as the template for the binding site used for the SMAP screen did not capture the six-molecule ring binding mode.
This binding site may explain the diverse inhibition profiles of 5-carboxamide and sufonamide-derivatized 1,3,4-thiadiazole-2-sulfonamides and offers a hot spot for designing isoform selective inhibitors, considering that residues 91 and 131 are highly variable among the 13 catalytically active isoforms.
This multitude of binding partners may explain the diversity of TSP-1 functions: TSP-1 modulates cell adhesion, migration, proliferation and differentiation regulating processes such as inhibition of angiogenesis (through CD36 and β1- integrin) and stimulation of neutrophil migration [28], [40], [41].
This unique binding pattern may explain the selective degradation of HP1α by DNA cross-linking.
