Sentence examples for binding may constitute a from inspiring English sources

DNA binding may constitute a more widespread and underappreciated mechanism by which histone demethylases identify target regions in the genome and catalyse demethylation.

Our findings suggest that ERK5-induced CREB-DNA binding may constitute a mechanism that triggers CREB to act as a repressor of gene expression.

The third sequence rule mapped does not immediately correlate with any known residues important for binding but does contain two positively charged residues that may be important in binding, thus these residues may constitute a novel functional region.

These results suggest that human apoA-I modulates Aβ aggregation and Aβ-induced neuronal damage and that the Aβ-binding domain in apoA-I may constitute a novel framework for the design of inhibitors of Aβ toxicity.

According to this structure the side chains of Gln69, Asn71 and Glu111 may constitute a malleable binding site capable of establishing various hydrogen bonds depending on the nature of the stacked bases [23].

Residues between 1,189 and 1,326 of ATRX serve as the dominant binding module for DAXX, and residues 321 865 of ATRX may constitute a secondary DAXX-interacting module (Tang et al., 2004).

The sequential binding of DevR to high affinity and low affinity sites may constitute a safety mechanism to tightly regulate induction and prevent regulon activation in the absence of the inducing signals.

Although detailed mechanism(s) underlying GSK-3 β regulation of NF- κB hetero- and homodimer formation and chromatin binding remain to be further characterized, the difference in DNA binding specificity/affinity as well as in transcriptional activity of NF- κB dimer forms may constitute a mechanism for selective activation/repression of a subset of NF- κB target genes.

Evidence of the frequent placement of the putative human-specific TF-binding sites within LADs suggests that at least some LADs in the human genome may constitute a component of the human-specific genomic regulatory network.

The acquired plasticity may constitute a gain of function as it would allow multiple induced conformations upon binding to the substrates, improving the binding diversity [29], [30].

The multiplicity of available applications to predict transcription factor binding sites in a particular locus contrasts with the substantial computational expertise that is demanded to manipulate them, which may constitute a potential barrier for the experimental community.