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These distinct differences in the electrostatic contribution to the free energy of binding may be the reason why predictions of the free energy of binding for complexes without capping are relatively more accurate.
Recent studies have pointed out that the induction of a quadruplex or change of a quadruplex conformation on binding may be the most powerful method to exert the desired biological effect.
These results suggest that the region in ErbB1, important for nucleolin binding, may be the ErbB1 nuclear localization sequence (NLS RRRHIVRKRTLRRRR (amino acids 669 681)).
However, it cannot be excluded that conformational changes in plasminogen upon EACA binding may be the reason for the inhibition rather than a competition for the lysine binding site [33], [34], [35], [36], since they could affect a possible lysine-independent binding motif of the protein.
Based on a functional analysis of cell proliferation and osteoblast differentiation, APR3 binding may be the mechanism by which Nell-1 promotes osteoblast differentiation [ 32].
Similar(55)
Therefore, an early event following integrin β1-binding may be the induction of a specific pathway or pathways, which relate to Rho.
Investigation of p.K167N mutation through molecular dynamics simulation and electrostatic analysis suggests that the ox-LDL binding may be attributed to the coupling between the electrostatic potential distribution and the asymmetric flexibility of the basic spine residues.
These spectroscopic studies suggest that absorption and emission changes upon HSA binding may be due to the dehydration of the dye and/or stabilization of the tritylic cation species.
These upstream differences, which can contribute to ligand binding, may be central to the selection of the predominant V(D J sequence for the corresponding CDR3 peptide.
However, the mechanism of cell-adhesion GPCR activation upon hormone binding may be different, because the GAIN domain lies between the HormR domain and the transmembrane helices.
Thus, one effect of IP6 binding may be to stabilize the open form of the hairpin.
More suggestions(16)
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binding may disturb the
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binding may hamper the
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binding may occlude the
binding may affect the
binding may support the
binding may invalidate the
binding may underlie the
binding may trigger the
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