Sentence examples for binding may be difficult from inspiring English sources
Such indirect binding may be difficult to detect with our ChIP assays and cannot be entirely excluded as a mechanism for the transactivation of the PLN promoter.
Based on these observations, we conclude that the generation of PXR antagonists targeted to the ligand binding pocket may be difficult due to the promiscuity and structural conformability of this xenobiotic sensor.
Current opinion suggests that classical competitive antagonists for PXR that bind in the ligand-binding pocket may be difficult to identify (Xue et al. 2007a) compared with allosteric antagonists that bind elsewhere on the protein surface (Ekins et al. 2007, 2008a).
It is possible that β3/β1 heterophilic binding has a lower affinity compared to homophilic binding such that it may be difficult to detect using assays based on the addition of free protein to cells in culture, compared to the higher concentrations possible within the lumen of the endoplasmic reticulum of cotransfected cells.
Although RIP allows identification of the target RNA molecules binding to an RBP, the data may include indirectly bound sequences, and precise locations of the binding site on the target mRNA may be difficult to determine.
Altogether, these results suggest that achieving a cytotoxic response following p53 reactivation may be difficult with mdm2/p53-binding antagonists.
Removing promiscuous binding or enzymatic activities by rational engineering, without compromising function, may be difficult given the long evolutionary selection for these attributes [ 30].
As a consequence, the adsorption of the binding complex of antigen-labeled antibodies on the surface of GNSTs may be difficult.
The binding of both carcinogens to blood proteins was low and suggests that human biomonitoring through protein adducts may be difficult.
