Post-transcriptional control of gene activity by RNA-binding proteins may be critical for tight regulation of signaling and, consequently, the control of cell differentiation.
Early experiments suggested that S. aureus binding to mucin may be critical for colonization of the nasophyngeal mucosa [ 37].
Overall, we have established a novel pipeline for the identification of TREs and provide a list of candidate binding sites that may be critical for normal TR-driven neurodevelopment.
Since DNA is a negatively charged, this positively charged region may be critical for DNA binding.
We use mutation analyses to explore which elements of secondary structure may be critical to p28 binding.
Increased hydrophilicity may reduce non-specific binding in the unbound state, and this may be critical for a naïve repertoire that is exposed to a diverse range of potential antigenic surfaces.
Further, it has been proposed that arousal levels, irrespective of emotional mood valence, may be critical for feature binding in working memory [4] and long-term memory for word lists [5].
Like Dok1 to Dok5, several tyrosine residues localise in the C-termini of Dok6, which may serve as binding sites for downstream targets and hence may be critical for downstream signal transduction.
Glycosidase digestion and mass spectrometric analyses have indicated that several mouse ZP3 terminal monosaccharide residues, including β- N-acetylgalactosamine (GalNAc), β- N-acetylglucosamine (GlcNAc), mannose, galactose, and sialyl, may be critical for sperm binding to the ZP.
The function of this structural specialization remained unknown, even though the second extracellular loop of certain types of mammalian G protein-coupled receptors may be critical for ligand binding and affinity [ 79, 80].
