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The other scenario is that the local conformation changes upon inhibitor binding may affect the AMF AMFR interactions.
Gefitinib binding may affect the extracellular part as well, with an apparent increase in EGF uptake, as observed both in gefitinib sensitive cells and in cells where growth rate is not affected [14].
Changes in protein binding may affect the concentration of unbound, ionized calcium and binding affinity, which is not predictable from one individual to another [ 4].
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To refine our search and identify regions in the promoter where TF binding may affect H4K5ac occupancy, we profiled the coverage of H4K5ac on all genes, on genes with a TFBS at 500 bp, 800 bp or 1100 bp upstream of the TSS, and on genes with no TFBS 100 bp upstream of the TSS.
The identification of the binding sites of naphthoquinones on DNA and the determination of how the binding may affect secondary and tertiary structures is still lacking.
The injury induced decrease in HNF4α binding may affect cellular transcription by simply decreasing the amount of effective HNF4α available for binding.
These results suggest that nucleotide binding may affect short- and long-range intermolecular forces by altering in part the hydrogen bonding network.
This nonspecific binding may affect AV-45 quantification when using whole-brain analyses.
With important interspecies variations, prednisolone protein binding may affect pharmacokinetic parameters such as drug concentration, volume of distribution, and elimination rate which could explain the differences in distribution process and volume between cats and humans [ 30].
As the changes in the HA receptor binding domain may affect the HA binding affinity or specificity, the above mentioned amino acid differences between Anhui1 and Shanghai1 may influence viral dependence on NA activity and sensitivity to NAIs.
Abolishment of the lag phase after addition of excess Ca2+, Mg2+, Mn2+, or Sr2+ suggests that binding of these metals in the peripheral binding sites may affect the TPQ conformation in the active site.
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