We note, however, that transcription factor binding motifs are usually very short and, hence, transcription factor binding look-alike sequences may arise in the genome by chance.
If batter is not binding or looks too dry, add the remaining egg.
We don't need more empty talk or finger pointing: They know what a fair, ambitious and binding deal looks like.
Ramming my left foot back into my binding, I looked round to see the rest of my mountaincraft coursemates waiting patiently, technical backpacks secure on their backs, neat outerwear perfectly suited to the terrain, powder skis floating primly on the snow, with the backdrop of the Dent du Géant dwarfing them.
162 pages with a vinyl cover and black tape binding – they look impressive!
The next step in this direction would be, instead of artificially manipulating the structures, tracing the coevolution of the transcription factor and all of the binding sites, looking at the in-vivo evolutionary optimization of recognition.
Taking advantage of this fact, we used an evolutionary proteomics approach to identify amino acids important for cytokinin binding by looking for residues conserved in cytokinin receptors, but not in other receptors.
A method of predicting whether or not a nucleotide change will have an effect on gene expression could be to score both the wild-type and the variant sequences for transcription factor binding and look for differences (GuhaThakurta et al. 2006).
It is also possible to explore novel binding modes, to look for compounds that interact with the target receptor in ways that are not seen with existing known ligands.
It is currently unclear to what extent and under what specific circumstances the documents might be binding on intensivists looking after legally incompetent patients.
