And there is probably no way that a clear, absolute, legally binding line can be drawn on the map between the terminal's aesthetic and its functional dimensions.
For instance, George D. Ittner, president and chief executive at the Newport News division of Spiegel Inc. in Downers Grove, Ill., which sells women's apparel and home furnishings through catalogs, said his company was making its name and logo "more prominent on catalogs, packages" and more closely monitoring how its catalogs are printed, from the "rotogravure plant to the binding line".
In this case, a binding line was drawn linking the second and third hits to the best hit of the same Citrus query.
Place the mounting disk into the leading foot binding, lining up the 15 degree angle notch with the binding's arrow.
Place the mounting disk into the back foot binding, lining up the 0 degree angle notch with the binding's arrow.
These findings are reminiscent of an earlier immunization of rabbits with CSA-binding IEs [26], in which antibodies reacted with diverse CSA-binding lines [26] but only inhibited the homologous parasite isolate [31].
To evaluate whether rabbit anti-DBL1-6 plasma or purified IgG could cross-inhibit binding of heterologous CSA-binding parasite lines expressing different VAR2CSA sequences, cross-inhibition experiments were performed against different CSA-binding lines.
Despite reacting with these parasite lines by flow cytometry (Table 1), rabbit anti-DBL1-6 plasma or purified IgG did not significantly inhibit binding of heterologous CSA-binding lines to CSA compared to the binding of the negative control CD36 binding parasite line to the CD36 recombinant protein (Figure 4B,C).
To examine antibody reactivity with native protein, immune plasma were screened against the homologous 3D7csa parasite and a panel of six well characterized CSA-binding lines from diverse worldwide geographic areas, including South America (7G8), Central America (HB3), and West Africa (Pf2004 and Pf2006).
In addition, immune plasma and purified IgG from mice and rabbits immunized with either the DBL4-6 or DBL1-6 recombinant proteins cross-reacted with multiple CSA-binding lines in the panel, although some parasite lines were recognized better than others (Figure 2, Table 1).
