Sentence examples for binding ligands that bind from inspiring English sources

Regional variability in sensitivity could result from localization of specific molecular targets in certain cell populations and the localization of transport and binding ligands that bind the metals to specific targets within each nephron [ 7].

Physiologically, the Logan-derived DV values are the most appropriate indicators of protein expression and/or receptor-ligand binding potential (Bmax/Kd) for ligands that bind reversibly.

Ligands that bind stably to G-protein uncoupled PTH1R [e.g. PTH (1-34)] produce a greater cAMP response for extended times after initial binding than ligands that bind with lower affinity [e.g., PTHrP (1-36)].

SR31747A is a recently described sigma receptor ligand that binds SR31747A-binding protein 1 (SR-BP) and emopamil-binding protein (EBP) (also called the sigma1 receptor and the human sterol isomerase (HSI), respectively), and has immunoregulatory and antiproliferative activities.

However, in 17 cases out of 24 cases, the top-scoring detected binding-site similarities for each case represent binding-sites in proteins that bind ligands that are similar to at least one of the substrates of the reaction catalyzed by the modelled C. difficile protein.

Recently, it was shown that the majority of FCD family members use three conserved histidines to bind a metal ion in the ligand binding cavity, suggesting that these regulators bind ligands that interact directly with the bound metal.

The molecular design is based on a pegylated cyclodextrin scaffold that bears both a heme-binding pocket and an axial ligand that binds an iron porphyrin.

Model T box antiterminator RNA is known to bind aminoglycosides, ligands that typically bind RNA in divalent metal ion-binding sites.

As shown in Fig. 5A, the mutation of the serine and glutamic acid to a histidine and valine residue at position αB1 and αB5 of the human LMO7 binding pocket conferred binding for ligands that were not bound by the wild-type PDZ domain.

The LBD consists of a ligand binding pocket that binds ligand, and an activation function 2 (AF2) region that binds cofactors.

Antibodies that compete with Notch1 ligand binding or that bind to the negative regulatory region can act as potent inhibitors of Notch1 signaling.