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Phage display selection of combinatorial peptide libraries has demonstrated its almost unlimited potential in identifying binding ligands for many targets.
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The three-domain design of HSA provides a variety of binding sites for many ligands, including heme, bilirubin and drugs.
The three-domain design of HSA provides a variety of binding sites for many ligands, including heme and drugs.
The polypeptide sequence is folded into a roughly U-shaped molecule, exposing well-characterized binding sites for many different ligands.
GABAA receptors also have binding sites for many other ligand molecules, some of which are widely used therapeutic drugs.
It was found to possess binding sites for many different substances, e.g. aromatic ligands, fatty acids and metals [ 23].
Such a cavity for binding ligands is lacking in HadB.
Such copper binding ligands are termed chalkophores, in analogy to siderophores involved in the iron uptake in many organisms.
These rapamycin-binding domains have been used for many applications including ligand-induced protein splicing and regulation of gene expression.
Upon ligand binding, many cell surface receptors become tyrosine phosphorylated, which provides binding sites for the SH2 domain of Grb2 [ 3].
For example, expression of the extracellular inhibitor of WNT signaling, secreted Frizzled-related protein 1 (sFRP1), which competes with FZD receptors for ligand binding, is downregulated in many breast tumors and is associated with poor prognosis [ 9- 11].
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