Sentence examples for binding ligand will be from inspiring English sources

Novel predictive biomarkers (e.g. radiolabelled oestradiol derivatives or PARP-1 binding ligand will be required for PET to fulfil these potential roles in studying the level and distribution of important targets.

The inverse triangle shows that with progress in the overall docking process, the number of feasible binding poses of a ligand will be reduced.

Otherwise, the uploaded kinase will be superimposed with the reference kinase (PDB ID: 4BKJ), and the ligands will be docked around its ligand binding site.

Thus, changes in HDX resulting from ligand binding will be scaled down, and the reductions in deuterium uptake upon binding of low affinity peptide ligands are likely to be small in magnitude.

The resulting web page with commented HTML/JavaScript code is shown in Additional file 2. In this section, the use of InCHlib for the exploration of the estrogen receptor α (ERα) ligand binding will be demonstrated.

A more detailed understanding of the dynamics of the protein under different conditions and the effect of ligand binding will be of interest to both areas of research.

According to these authors, if the enthalpically driven ligand binding shifts the conformation of a protein from the "low entropic" state to the "high entropic" state, the enthalpic gain (due to ligand binding) will be essentially transduced (compensated) into the entropic changes in the protein structure.

The successful applications in molecular design described in literature using predicted polypharmacology in protein-ligand binding will be shown and the analogy in the design of protein-protein interaction inhibitors and the potential of polypharmacology prediction will be discussed.

If a conformation capable of recognizing a specific ligand is only populated a fraction of the time, unless that conformation has a high intrinsic affinity for the ligand, the overall binding affinity will be very weak, as the effective concentration of binding-competent receptor is reduced.

This flexible mapping between receptors and ligands is called degeneracy [ 4], which means a low binding energy will be signaled.

A set of top ranked binding poses will be locally optimized within the protein binding site to obtain the final ligand binding pose and binding score.