Sentence examples for binding ligand indicating that from inspiring English sources

In fact, recently Perrone and co-workers published results showing that HIV-1 promoter activity is impaired in the presence of a G-quadruplex binding ligand, indicating that indeed the structures have a role in regulating virus expression.

We then determined that virus removal by this chromatography resin is strongly disrupted by the presence of high salt concentrations or by the absence of the positively charged Q ligand, indicating that binding of the virus to the resin is primarily due to electrostatic forces, and that any non-electrostatic interactions which may be present are not sufficient to provide virus removal.

The term multprotein ligand indicates that the direct binding partners of the considered scaffold can also recruit further proteins or scaffolds (see Figure 1).

The term single protein ligand indicates that one only considers the multi domain protein and its direct binding partners but no additional binding or modification processes at these ligands.

Removing the O-glycans on α-DG abolishes its ligand binding, indicating that the O-glycans are essential for the activity [4], although the exact structure of the O-glycans mediating its ligand binding remains largely unknown.

Testing of the pH sensitivity of ligand binding indicated that, as with human LSECtin, the binding activity of mouse LSECtin is enhanced at low pH.

Kinetic analyses of ligand binding indicate that the Bohr and Root effects of Amia calva hemoglobins are best explained by changes in both the "on" and "off" constants.

Unlike all the TRAPS mutations, the rare TNFR1 variant R92Q behaves similarly to wild-type TNFR1 in terms of ligand binding and trafficking, indicating that the mechanism of disease associated with this variant receptor is probably different to that of the mutations strictly associated with TRAPS.

We found that the association was not dependent on ligand (DPN) binding to ERβ indicating that the protein complex is pre-formed within the nucleus.

Computer modelling of ligand binding data indicate that the binding of -[3H]dihydroalprenolol to these sites conforms closely to the pattern anticipated for interactions of the ligand with a homogeneous class of receptors according to the law of mass action.

The background binding (i.e., binding to GST-hPXR-LBD in the presence of TO901317 [ 1, 10 μM]) of BODIPY FL vinblastine (4) and BODIPY FL vindoline (20) was almost identical to the absolute background binding, indicating that 10 μM PXR ligand TO901317 (1) effectively inhibited the interactions between PXR and BODIPY FL vinblastine (4) or BODIPY FL vindoline (20).