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HDACi should cover HDAC2 in their inhibitory profile and timing and dosing regimen in clinical trials should take binding kinetics of compounds into consideration.
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Simulation of clinical pharmacokinetics showed time-dependent on target activity that correlated with binding kinetics of HDACi compounds.
Equilibrium binding and binding kinetics of BMS-681 and CCR2-RA-[R] with WT CCR2 and CCR2-T4L.
Here, we use surface plasmon resonance to quantitate the binding kinetics of RGM proteins for BMP ligands.
Biolayer interferometry (Octet RED96, FortéBio) experiments at 25 °C were conducted to determine the epitope bins and binding kinetics of selected Fabs for Pfs25.
Gadola SD, Koch M, Marles-Wright J, Lissin NM, Shepherd D, Matulis G et al. Structure and binding kinetics of three different human CD1d-alpha-galactosylceramide-specific T cell receptors.
"Binding kinetics of superantigen with TCR and MHC class II". Methods Mol Biol 214 (2003): 65-85.
The binding kinetics of 11B6 were analysed on a Biacore instrument.
Measurements of Ca2+ binding kinetics of YC3.60 were performed as shown previously [11].
Our own SPR experiments, which measured the binding kinetics of the TCR to glycolipid-loaded hCD1d for the thioamide and carbamate analogues of α-GalCer and ThrCer, show that these molecules also display similar or poorer TCR binding kinetics compared to the parent compounds.
Next we investigated the binding kinetics of BAY 85-8501 (Table 7).
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