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ADA binding is unique to DPP-4 among DASH family and DPP-4 inhibitor was reported not to affect this binding [ 14].
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The ability to hyperglycosylate α-DG and "rescue" its laminin binding activity is unique to LARGE and its homolog LARGE2 [46] [48].
Unlike CSA binding that is unique to PAM parasites, in vitro interaction of individual DBL with CSA is often seen with non-VAR2CSA DBLs.
If a true binding site is unique to a genome, then it will not score high.
The conserved and protein-specific monovalent cation-binding site is unique to the GHKL superfamily and probably essential for both ATPase and kinase activity.
The specificity of its target binding is unique, and target affinity is comparable to clinically used gpIIb/IIIa antagonists.
PKCε contains an actin binding motif that is unique to this individual member of the PKC family [37] suggesting that this isozyme may be playing a role in this context.
This halogen group occupies a pocket in the SAM-binding site which is unique to DOT1L and is responsible for the high selectivity of bromo-SAH over other methyl transferases.
Our current analysis indicated that the C-terminal cargo-binding domain that is unique to animal type VI myosins is evolutionarily related to the immunity protein Imm-MyosinVICBD [ 210] (p = 10-7 iterationion 4 with JACKHMMER in a search initiated with an immunity protein gi: 332655030) that is predicted to counter certain ADP-ribosyltransferase toxins.
Independent of the mechanism by which Gβγ activates downstream signaling in this paradigm, we hypothesize that the Gβγ subunits released from CRFR1 in response to ligand binding are unique in their ability to elicit downstream CREB phosphorylation, insofar as dissociation of Gβγ from any GPCR is insufficient for this effect.
Interestingly, only one common binding motif was found in the two sets, while the rest of the binding motifs were unique to each set (Tables 11 and 12).
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