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This binding is transmitted to downstream effectors in the cytoplasm through activation of heterotrimeric G-proteins.
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In addition, it is unclear how the presence or absence of tryptophan in the binding pocket is transmitted to the RNA-binding site.
According to the present model an extracellular binding event is transmitted to the cytoplasmic domain that links the transmembrane protein to the actin/myosin motor of the sporozoite (Keeley and Soldati, 2004; Schüler and Matuschewski, 2006).
This raises questions about how the light signal is transmitted to the DNA-binding part of the protein and how this affects the DNA binding of aureochromes.
Notch pathway activity is transmitted to target genes by binding of the activated Notch intracellular domain (NICD) to the CBF1/Suppressor of Hairless/LAG-1 (CSL) DNA-binding protein.
This power is transmitted to the ground through aluminium cables.
This virus is transmitted to humans by mosquitoes.
It is transmitted to humans by the Aedes ssp mosquitoes.
Molecular dynamics simulations and quasi-harmonic analyses suggest that the effect of inhibitor binding is transmitted from the dimer interface to the active-site loops that are known to assume an obligatory ordered substructure during catalysis.
Although the exact mechanistic details of how distant binding is transmitted through the protein are not revealed by these data, the ability of GNF-5 to inhibit kinase activity on its own in both wild-type and T315I Abl (Fig. 1) must be related to these changes in protein dynamics and point to an allosteric mechanism by which GNF-5 binding is communicated to the ATP site.
The signal induced by ligand binding is transmitted intracellularly by a process involving proteolytic cleavage of the receptor and nuclear translocation of the intracellular domain of the Notch family protein.
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CEO of Professional Science Editing for Scientists @ prosciediting.com