Sentence examples for binding is the initial from inspiring English sources

With exceptions such as rhodopsin which has a permanently bound inverse agonist, retinal, ligand binding is the initial event for signal transduction through the membrane via conformational changes in the helix arrangement [16], [19], [20], [27], [54].

Given that the initiator consensus is the initial binding site for RNA polymerase II, it is not far-fetched to speculate that small differences in the sequence may play a role in determining either the affinity of polymerase II or the energy required to separate the DNA strands and initiate transcription; both of which could potentially modulate the quantity of transcript produced.

For very potent, high-affinity compounds this assumption may not be valid, and under such conditions the concentration of unbound drug will be affected by its binding to the pharmacological target and the binding model becomes 3: is.2where L0 is the initial, total drug concentration.

In particular, it is possible that DR3 binding to E-selectin is the initial event that activates E-selectin oligomerization and thereby ERK-mediated disruption of the adherent junctions and diapedesis [ 38].

The high electronegativity of the foot loop) could aid in the weak longer-range nonspecific binding, proposed to be the initial phase of the fly casting binding process [ 52].

A key requirement for induced-fit binding is an initial 'loose' contact between the two molecules, followed by structural adaptations to form a higheraffinity complex.

For bridging of laminin and collagen IV networks nidogen-laminin binding had been assumed to be the initial step [ 99, 101, 108, 109].

Total binding at 4°C was assumed to be the initial surface receptor occupancy.

We show that the initial binding is mediated by the diffusion of the protease along the ordered helix on the collagen ¾ fragment, with preferential binding of the collagen tail.

The observation that the rate of displacement of Dauda by TBA is independent of the concentration of TBA (Table 2) shows that the rate of TBA binding is controlled by some initial slow step before the actual binding event.

Therefore, though the epitope required for 2G12 binding was present in the initial virus, its resistance to neutralization could be due to masking of the epitope through certain amino acid changes that probably caused folding patterns.