Sentence examples for binding is sufficient to from inspiring English sources
Based on our conclusion that Jak2 binding is sufficient to inhibit GHR endocytosis, we hypothesised that Jak2 must leave the GHR before the endocytosis machinery, including SCF βTrCP) and clathrin, can proceed [16].
These results suggest that, 1) inhibition of polyubiquitin binding is sufficient to inhibit gp78-p97/VCP gp78-p97/VCP or 2) htt and antinteractionn antibory binding sterically blocks p97/VCP binding to its binding site [the p97/VCP-Interacting Motif (VIM)] in gp78 [52].
This suggests that ORC binding is sufficient to determine a eukaryotic replication origin.
It appears that the alteration in bias of the G1Δnab constant region away from activatory receptor binding is sufficient to prevent destruction of these platelets.
We find that Arg-SH3SH2 binding is sufficient to activate N-WASp, or phospho-N-WASp, even in the absence of Cdc42.
The authors have found that ATP binding is sufficient to initiate a signaling response in the presence of an optimal RNA ligand.
Thus the ATP switch model proposes that the conformational changes associated with ATP binding are sufficient to switch the substrate-binding site from high to low affinity, thus releasing the substrate on the other side of the membrane [ 54].
After finding that Ku was unable to promote extensive telomere elongation in the presence of a Cdc13– Est2 fusion in the absence of TLC1 binding, we wanted to know if Ku's interaction with TLC1 in the absence of DNA binding was sufficient to promote telomere elongation.
We assume, however, that there are some TF TFBS pairs that are sufficiently critical such that r > r * and loss of cross-binding is sufficient to decrease the gene expression level to the extent that the hybrid is inviable; these are the pairs that will be relevant for the speciation process and therefore are the ones addressed by our model.
