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First, etanercept binding is restricted to the trimeric form of soluble TNF, whereas infliximab binds to both monomer and trimer forms.
To test, both in semen and washed-sperm fractions, whether hyaluronic acid (HA) binding is restricted to sperm that have completed cellular maturation.
Previous studies by Walenkamp et al. and Schelenz et al. showed that in vitro, SP-A binding is restricted to acapsular and minimally encapsulated strains of C. neoformans [10], [11].
In contrast to DDR2, which binds to several Toolkit peptides derived from type II and type III collagens, DDR1 binding is restricted to the GVMGFO motif [51].
The authors showed that cetuximab was bound by α-Gal-specific IgE antibodies in the serum of patients and that this binding is restricted to the Fab domain.
IgM binding is restricted to the microvasculature, and none of the 20 adenocarcinomas investigated showed IgM binding to proliferating (Ki67+) or differentiating malignant cells.
Similar(51)
Heparin/sulfatide binding was restricted to IG5 and shown to depend on four arginine residues that are close in space in β strands B and E of the C-type IG fold.
OG488-FXa binding was restricted to small structures, resulting in a fluorescence surface area coverage of 9.6±1.2% (Fig. 3B).
As previously reported for other serotypes [54], [55], we observed that when S. pyogenes expressed WT levels of M protein on their surface, very little C3 was deposited, and its binding was restricted to small patches on the cell.
In the HoxB cluster, Meis binding was restricted to the Hoxa2 paralog Hoxb2 (albeit with a lower peak).
It is interesting that when HA binding was restricted to a specific subset of patients with low binding, the same patients showed the greatest benefit (Worrilow et al., 2013).
More suggestions(17)
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