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H1 binding is reduced in cytoplasm, and H1 exhibits rapid FRAP dynamics in cytoplasm but not in buffer.
Moreover, GABA-A receptor binding is reduced in patients with panic disorder and other anxiety-related disorders [14], and mice deficient of GAD 65 have deficits in consolidation and generalization of fear memory [15], [16].
The binding of POF and HP1 is interdependent, hence POF binding to the fourth is strongly reduced in HP1 mutants and HP1 binding is reduced in Pof mutants (Johansson et al. 2007a).
Furthermore, though not significantly different from that of the age-matched controls, Ku-DNA binding is reduced in extracts of post-mortem AD mid-frontal cortex, and this could be attributed to reduced levels of Ku subunits and DNA-PKcs [ 73].
The less reactive conformation of the active site cysteine, together with the observation that the side chain of Phe26 transiently occupies the ligand-binding space in the apo simulations, suggests that the probability of spontaneous ligand binding is reduced in the unliganded state.
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Furthermore, the D2 receptor density in a midbrain membrane preparation, determined by radioligand binding, was reduced in the samples from GFP-D2 animals compared to WT (Fig. 2H).
In higher brain centres, [3H]NBTI binding was reduced in the paraventricular thalamic nucleus of both heterozygous and homozygous mice, whereas [3H]DPCPX binding was reduced in the hippocampus and lateral hypothalamus of heterozygotes.
After adolescent nicotine treatment (postnatal days 30-47), PXT binding was reduced in the hippocampus and striatum instead of the cerebral cortex, again accompanied by increased binding in the midbrain and brainstem; the patterns of effects within each region were gender-selective, although both males and females displayed abnormalities.
Furthermore, both AP-2α and HDAC binding was reduced in the AP-2α downregulated cells.
Herein we report results from additional bioassays with Cry1Ab and Cry2Ae, as well as analyses to determine whether Cry2Ab binding was reduced in the field-isolated resistant insects and if the occurrence of shared binding sites could account for the cross-resistance patterns that we observed.
Using the MC lysate as the serum inhibitor, specific IgE binding was reduced in a dose-dependent manner.
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