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These studies show that nisin does bind lipid II on spores but that lipid II binding is not sufficient for outgrowth inhibition, whereas membrane disruption is essential.
Pho4 binding is not sufficient for transcriptional activation a cooperative interaction between Pho2 and Pho4 specifies genes that are activated.
Despite the reductions in protease sensitivity, MMP-1 bound to all of the engineered rhCIIIs with comparable affinity, indicating that MMP-1 binding is not sufficient for cleavage.
However, nucleotide binding is not sufficient to close the folding chamber.
Third, mere TF binding is not sufficient to guarantee its regulation.
In fact, mere TF binding is not sufficient to guarantee its regulation.
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Nevertheless, our data demonstrated that bivalent CD4 binding was not sufficient to induce CD4 down-modulation.
However, no structural differences were observed between apo form and GDP-bound configurations of BsObg, implying that conformational changes associated with GDP binding are not sufficient to affect the Obg domain movement [24].
However, this binding was not sufficient to result in NV infection and replication within these cell types (5 ).
In contrast, Pfh1 was detected at 40% of Class III sites, but this binding was not sufficient to prevent damage in WT cells.
However, we observed that C-terminal region of FUS involved in RNA recognition and binding was not sufficient to target the protein to paraspeckles (Fig. 1C and D, panel CT).
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