Sentence examples for binding is not necessary from inspiring English sources

Together, these findings indicate that NRP1 plays a role in regulating the cell surface expression of VEGFR2 in endothelial cells and that VEGF-NRP1 binding is not necessary for this function in vivo.

Consistent with our observation in Dicer-depleted cells, wild-type and YA/FA mutant Ago2 associated equally well with Rad51, indicating that sRNA binding is not necessary for Ago2 to interact with Rad51.

It seems likely that only multivalent MHC interactions can induce structural rearrangement of the TCR so that Tyr rich regions are exposed., CD4/CD8 binding is not necessary for TCR activation but high affinity binding to the receptor is necessary.

An interaction within the cofactor binding site is not necessary to obtain this high binding affinity for substances developed.

However, as shown in the present study and in at least 3 other KO models (ADAM1a, ADAM3 and PDILT; refs. 21, 26), the avid binding of acrosome-intact spermatozoa to the zona demonstrable in sperm-egg binding assays is not necessary for fertilization and may simply be a laboratory artifact.

The observation was rationalized by the extra entropic cost associated with reorientation of the F296 and Y375 side chains upon "normal" substrate binding, which is not necessary in the "flipped" mode.

First of all, we confirmed previous data indicating that the RNA-binding activity is not necessary for TDP-43 aggregation (16).

Furthermore, neutral dextrans of the same molecular weight showed minimal binding to particles but were still effectively chaperoned by particles into cytosol, suggesting that binding to particles is not necessary for the observed particle-mediated cytosolic delivery.

In addition, some critics argue that a universally applicable and binding moral code is not necessary for meaning in life, even if the act of helping others is (Ellin 1995, 327).

A double mutant showed no further reduction, suggesting that binding to PRR1 is not necessary for activity.

We did not see disinhibition with MAG R118A indicating that sialic acid binding of MAG is not necessary for inhibiting sensory neurons, thus confirming data obtained with CGN.